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Half-inhibition Concentrations of New Cholinesterase Inhibitors

Author:
Pavla Zdražilová, Šárka Štĕpánková, Karel Komers, Karel Ventura, Alexander Čegan
Source:
Zeitschrift für Naturforschung 2014 v.59 no.3-4 pp. 293-296
ISSN:
1865-7125
Subject:
Alzheimer disease, acetylcholinesterase, carbamates, cholinesterase, cholinesterase inhibitors, drugs, enzyme activity, hydrolysis, therapeutics
Abstract:
The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI₅₀ values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI₅₀ values of the commercially used drugs for the Alzheimer’s disease treatment - rivastigmine and galanthamine.
Agid:
5230495