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Antibacterial and Antioxidant Activity and Essential Oil Composition of Grammosciadium scabridum Boiss. from Iran

Sonboli, Ali, Salehi, Peyman, Kanani, Mohammad Reza, Ebrahimi, Samad Nejad
Zeitschrift für Naturforschung 2014 v.60 no.7-8 pp. 534-538
2,2-diphenyl-1-picrylhydrazyl, Apiaceae, antioxidant activity, bacteria, essential oils, free radical scavengers, gamma-terpinene, inhibitory concentration 50, minimum inhibitory concentration, oils, p-cymene, screening, Iran
The in vitro antibacterial and antioxidant activity of the essential oil and its two main components of Grammosciadium scabridum Boiss. (Apiaceae) growing wild in Iran, as well as the composition of its essential oil were studied. A total of 19 compounds representing 99.9% of the oil has been identified. γ-Terpinene (73.5%), p-cymene (14.2%) and (E)-β-farnesene (5.3%) were characterized as the main components. The oil showed remarkable activity against three Gram-negative and four Gram-positive test bacteria, with minimal inhibitory concentration (MIC) values ranging from 0.31 to 10.00 mg/ml. The oil and its two main components were also subjected to screening for their possible antioxidant activity by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The free radical scavenging capacity of the oil was determined with an IC₅₀ value of 6.6 mg/ml.