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Cytotoxic β-Dihydroagarofuran Sesquiterpenoids from the Fruits of Celastrus orbiculatus

Author:
Xu, Jing, Guo, Yuan-Qiang, Li, Xian, Wei, Kun, Zhao, Xiaojun, Zhang, Shuzhong
Source:
Zeitschrift für Naturforschung 2014 v.63 no.7-8 pp. 515-518
ISSN:
1865-7125
Subject:
Celastrus orbiculatus, cytotoxicity, fractionation, fruits, humans, melanoma, sesquiterpenoids, structure-activity relationships, uterine cervical neoplasms
Abstract:
Assay-guided fractionation led to the isolation of nine β-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus. All isolated β-dihydroagarofuran sesquiterpenoids were tested for their cytotoxic activity against human melanoma A375-S2 and human cervical carcinoma Hela cell lines. Among them, compounds 1-5 and 7 showed cytotoxic activity. Compound 3 exhibited promising cytotoxicity against both human melanoma A375- S2 and human cervical carcinoma Hela cell lines. The structure-activity relationship was discussed briefly.
Agid:
5231082