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GC-MS Investigation and Acetylcholinesterase Inhibitory Activity of Galanthus rizehensis

Author:
Buket Bozkurt Sarikaya, Nehir Unver Somer, Gulen Irem Kaya, Mustafa Ali Onur, Jaume Bastida, Strahil Berkov
Source:
Zeitschrift für Naturforschung 2014 v.68 no.3-4 pp. 118-124
ISSN:
1865-7125
Subject:
Galanthus, acetylcholinesterase, aerial parts, alkaloids, bulbs, fruiting, gas chromatography-mass spectrometry, inhibitory concentration 50, vegetation
Abstract:
GC-MS (gas chromatography-mass spectrometry) analyses of alkaloids in the aerial parts and bulbs of Galanthus rizehensis Stern (Amaryllidaceae), collected during two different vegetation periods, was performed. Twenty three alkaloids were identified in four different alkaloid extracts. Acetylcholinesterase (AChE) inhibitory activities of the alkaloid extracts were tested. Both the highest alkaloid diversity and the most potent inhibitory activity (IC₅₀ 12.94 μg/ml) were obtained in extracts from the bulbs of G. rizehensis collected during the fruiting period.
Agid:
5231534