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Design, Synthesis, and Evaluation of Novel Auxin Mimic Herbicides

Author:
Do-Thanh, Chi-Linh, Vargas, Jose J., Thomas, Joseph W., Armel, Gregory R., Best, Michael D.
Source:
Journal of agricultural and food chemistry 2016 v.64 no.18 pp. 3533-3537
ISSN:
0021-8561
Subject:
Zea mays, auxins, broadleaf weeds, herbicides, sweetcorn, weed control
Abstract:
Due to the key roles of auxins as master regulators of plant growth, there is considerable interest in the development of compounds with auxin-like properties for growth management and weed control applications. Herein, we describe the design and multistep synthesis of ten compounds bearing combinations of functional groups commonly associated with auxin-type properties. Following synthesis, these compounds were tested against multiple weed species as well as sweet corn. In general, while these structures were not quite as active as commercial auxin mimic herbicides, multiple compounds exhibited broadleaf weed activity with concurrent selectivity in sweet corn (Zea mays L. var. saccharum). In addition, differential results were observed upon subtle changes to structure, providing insights into the structural properties required for activity.
Agid:
5234242