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Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake

Sandhu, Amandeep K., Huang, Yancui, Xiao, Di, Park, Eunyoung, Edirisinghe, Indika, Burton-Freeman, Britt
Journal of agricultural and food chemistry 2016 v.64 no.24 pp. 4891-4899
adults, anthocyanins, beverages, bioavailability, body mass index, breakfast, liquid chromatography, metabolites, overweight, pelargonidin, pharmacokinetics, spectrometers, strawberries
Plasma strawberry anthocyanins were characterized in overweight (BMI: 26 ± 2 kg/m2) adults (n = 14) on the basis of meal timing. At each visit, subjects ingested three study drinks: two control and one strawberry drink. A strawberry drink was given at either 2 h before the breakfast meal (BM), with the meal (WM), or 2 h after the meal (AM), and control drinks were given at the alternative time points. Plasma anthocyanins and their metabolic conjugates were assessed hourly for 10 h using a triple-quadrupole liquid chromatography mass spectrometer. Maximum concentrations (Cmax), area under the curve (AUC), and bioavailability of pelargonidin-based anthocyanins determined from the main conjugated metabolite (pelargonidin glucuronide) were greater when a strawberry drink was consumed 2 h before the meal (BM) compared to consumption WM or AM (p < 0.05). Our results indicate that the timing of strawberry consumption relative to a meal impacts anthocyanin pharmacokinetic variables.