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Neonatal Mortality, Vesicular Lesions and Lameness Associated with Senecavirus A in a U.S. Sow Farm

Author:
Canning, P., Canon, A., Bates, J. L., Gerardy, K., Linhares, D. C. L., Piñeyro, P. E., Schwartz, K. J., Yoon, K. J., Rademacher, C. J., Holtkamp, D., Karriker, L.
Source:
Transboundary and emerging diseases 2016 v.63 no.4 pp. 373-378
ISSN:
1865-1674
Subject:
Deltacoronavirus, Foot-and-mouth disease virus, Porcine epidemic diarrhea virus, Porcine reproductive and respiratory syndrome virus, Seneca Valley virus, Transmissible gastroenteritis virus, adults, animal diseases, animal health, biosecurity, blood serum, breeding stock, case studies, cell culture, disease course, emerging diseases, farms, feces, feet, genes, lameness, males, morbidity, neonatal mortality, pathogens, piglets, reverse transcriptase polymerase chain reaction, risk, sows, tissues, veterinarians, United States
Abstract:
A 300‐sow farrow‐to‐finish swine operation in the United States experienced a sudden and severe increase in mortality in neonatal piglets with high morbidity followed by vesicular lesions on the snout and feet of adult females and males. Affected live piglets were submitted for diagnostic investigation. Samples tested polymerase chain reaction (PCR) negative for foot‐and‐mouth disease virus, porcine delta coronavirus, porcine epidemic diarrhoea virus, porcine rotavirus types A, B and C, transmissible gastroenteritis virus, and porcine reproductive and respiratory syndrome virus. Senecavirus A (SV‐A) formerly known as Seneca Valley virus was detected by real‐time reverse‐transcription polymerase chain reaction (rRT‐PCR) from serum, skin and faeces of piglets and from serum and faeces of sows. SV‐A was isolated in cell culture from piglet samples. SV‐A VP1 gene region sequencing from piglet tissues was also successful. A biosecurity and disease entry evaluation was conducted and identified potential biosecurity risks factors for the entry of new pathogens into the operation. This is the first case report in the United States associating SV‐A with a clinical course of severe but transient neonatal morbidity and mortality followed by vesicular lesions in breeding stock animals. Veterinarians and animal caretakers must remain vigilant for vesicular foreign animal diseases and report suspicious clinical signs and lesions to state animal health authorities for diagnostic testing and further investigation.
Agid:
5241257