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Triterpenoids from the stems of Schisandra grandiflora and their biological activity

Author:
Shi, Wei, Liu, Han-Wei, Guo, Xin, Hou, Lan, Gao, Jin-Ming
Source:
Journal of Asian natural products research 2016 v.18 no.7 pp. 711-718
ISSN:
1477-2213
Subject:
Alternaria alternata, Alternaria solani, Schisandra, anticarcinogenic activity, antifungal properties, cytotoxicity, fungi, growth retardation, human cell lines, humans, neoplasms, plant pathogens, spectroscopy, stems, triterpenoids
Abstract:
One new ursane-type triterpenoid (1), named granditriol, along with 14 known compounds (2 – 15), was isolated from the organic extracts of Schisandra grandiflora stems. The structure of the new compound was elucidated by extensive spectroscopic methods as 28-norursa-12,17,19,21-tetraen-2 α ,3 α ,23-triol. These isolates were evaluated for anti-phytopathogenic fungi activity and cytotoxicity against human cancer cell line (HepG2). Asiatic acid (8) and 2 α ,3 α ,19 α -trihydroxyurs-12-en-28-oic acid (9) inhibited the growth of two plant pathogens, Alternaria alternata and Alternaria solani . In addition, compounds 12 , 15 , and 11 displayed notable anti-proliferative activity against HepG2 cells. Compound 1 is the first report of 28-nortriterpenoid from the Schisandraceae family. All these were obtained from this plant for the first time.
Agid:
5241874