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Trichocitrin, a new fusicoccane diterpene from the marine brown alga-endophytic fungus Trichoderma citrinoviride cf-27

Author:
Liang, Xiao-Rui, Miao, Feng-Ping, Song, Yin-Ping, Guo, Zhan-Yong, Ji, Nai-Yun
Source:
Natural product research 2016 v.30 no.14 pp. 1605-1610
ISSN:
1478-6427
Subject:
Escherichia coli, Prorocentrum, Trichoderma citrinoviride, diterpenoids, fungi, growth retardation, nuclear magnetic resonance spectroscopy, secondary metabolites, spectral analysis
Abstract:
One new diterpene, trichocitrin (1), and four known secondary metabolites, nafuredin (2), 5-hydroxy-2,3-dimethyl-7-methoxychromone (3), 24-methylenecycloartanol (4) and citrostadienol (5), were isolated from the culture of marine brown alga-endophytic Trichoderma citrinoviride cf-27. Trichocitrin (1) represents the first Trichoderma -derived and furan-bearing fusicoccane diterpene, and its structure and relative configuration were identified by analysis of 1D/2D NMR and mass spectroscopic data. Compounds 1 and 2 exhibited 8.0- and 9.5-mm inhibition zones, respectively, against Escherichia coli at 20 μg/disc and 54.1 and 36.7% growth inhibition, respectively, of Prorocentrum donghaiense at 80 μg/mL.
Agid:
5242000