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A highly efficient and enantioselective synthesis of EEHP and EMHP: intermediates of PPAR agonists

Author:
Gangar, Mukesh, Harikrishnan, M., Goyal, Sandeep, Mungalpara, Maulik N., Nair, Vipin A.
Source:
Tetrahedron letters 2016 v.57 pp. 3462-3467
ISSN:
0040-4039
Subject:
agonists, alkylation, bromides, enantiomers, organic compounds, peroxisome proliferator-activated receptors, stereochemistry
Abstract:
Glycolate alkylation reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one auxiliary has been optimised with high yields and diastereoselectivity on substituted benzyl and allyl bromides. The standardised reaction condition was employed for the stereoselective synthesis of EEHP and EMHP intermediates of PPAR agonists.
Agid:
5244306