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Design of binary polymeric platforms containing ɩ-carrageenan and hydroxypropylcellulose for use in cataract surgery

Jones, David S., Rafferty, Gerard P., Andrews, Gavin P.
Carbohydrate polymers 2016 v.154 pp. 296-304
adhesion, cataract, compressibility, gels, hardness, loss modulus, mechanical properties, physicochemical properties, polymers, rheometry, surgery, texture, viscoelasticity
This study describes the design and characterisation of the rheological and mechanical properties of binary polymeric systems composed of 2-Hydroxypropylcellulose and ɩ-carrageenan, designed as ophthalmic viscoelastic devices (OVDs). Platforms were characterised using dilute solution, flow and oscillatory rheometry and texture profile analysis. Rheological synergy between the two polymers was observed both in the dilute and gel states. All platforms exhibited pseudoplastic flow. Increasing polymer concentrations significantly decreased the loss tangent and rate index yet increased the storage and loss moduli, consistency, gel hardness, compressibility and adhesiveness, the latter being related to the in-vivo retention properties of the platforms. Binary polymeric platforms exhibited unique physicochemical properties, properties that could not be engineered using mono-polymeric platforms. Using characterisation methods that provide information relevant to their clinical performance, low-cost binary platforms (3% hydroxypropylcellulose and either 1% or 2% ɩ-carrageenan) were identified that exhibited rheological, textural and viscoelastic properties advantageous for use as OVDs.