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Antibacterial electrospun chitosan–polyethylene oxide nanocomposite mats containing bioactive silver nanoparticles
- Kohsari, Iraj, Shariatinia, Zahra, Pourmortazavi, Seied Mahdi
- Carbohydrate polymers 2016 v.140 pp. 287-298
- Escherichia coli, Falcaria, Fourier transform infrared spectroscopy, Staphylococcus aureus, antibacterial properties, bacteria, contact angle, differential scanning calorimetry, energy-dispersive X-ray analysis, hydrophilicity, nanocomposites, nanofibers, nanosilver, scanning electron microscopy, silver, tensile strength, thermogravimetry
- The antimicrobial chitosan–polyethylene oxide (CS–PEO) nanofibrous mats were developed by electrospinning technique for wound dressing applications. Indeed, a green route was introduced for fabrication of antibacterial mats loaded with 0.25% and 0.50% (w/w) of bioactive silver nanoparticles (Ag NPs, ∼70nm diameter) reduced by Falcaria vulgaris herbal extract. The mats were characterized by FE-SEM, EDAX, elemental mapping, FT-IR, contact angle, TGA/DSC as well as tensile strength analysis. All of the nanofibers had an average ∼200nm diameter. Interestingly, both of the CS–PEO mats containing 0.25% and 0.50% bioactive F. vulgaris-Ag NPs revealed 100% bactericidal activities against both Staphylococcus aureus and Escherichia coli bacteria. The silver release from nanofiber mats was sharply increased within first eight hours for both CS–PEO mats including 0.25% and 0.50% F. vulgaris-Ag NPs but after that the Ag nanoparticles were released very slowly (almost constant). The improved hydrophilicity, higher tensile strength and much greater silver release for CS–PEO-0.50% F. vulgaris-Ag NPs relative to those of the CS–PEO 0.25% F. vulgaris-Ag NPs suggested that the former was superior for biomedical applications.