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Six new dihydrobenzofuran lignans from the branches and leaves of Illicium wardii and their cytotoxic activities

Author:
Ye, Feng-mei, Xie, Yang-guo, Ren, Jie, Ye, Ji, Guo, Yi-gong, Yan, Shi-Kai, Jin, Hui-Zi, Zhang, Wei-Dong
Source:
Phytochemistry letters 2016 v.17 pp. 263-269
ISSN:
1874-3900
Subject:
Illicium, branches, cytotoxicity, humans, inhibitory concentration 50, leaves, lignans, neoplasms, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Six new dihydrobenzofuran lignans, named illiciumlignans A⿿F (compounds 1⿿6), along with 15 known compounds (7⿿21) were isolated from the branches and leaves of Illicium wardii. The structures of 1⿿6 were determined using a combination of 1D and 2D NMR, HR-ESI⿿-MS, and CD spectroscopic data. Illiciumlignan D (4) is the first reported dihydrobenzofuran lignan arabinofuranoside that is derivatized with the arabinofuranose moiety on C-9⿲. Compounds 1⿿21 were evaluated for cytotoxic activity against four human cancer cell lines. Compounds 8, 12 and 20 exhibited significant activity against human cancer cell lines (A549, SKOV3, HepG2 and HCT116), with IC50 values ranging from 2.7 to 14.9μM.
Agid:
5245065