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Six new dihydrobenzofuran lignans from the branches and leaves of Illicium wardii and their cytotoxic activities
- Ye, Feng-mei, Xie, Yang-guo, Ren, Jie, Ye, Ji, Guo, Yi-gong, Yan, Shi-Kai, Jin, Hui-Zi, Zhang, Wei-Dong
- Phytochemistry letters 2016 v.17 pp. 263-269
- Illicium, branches, cytotoxicity, humans, inhibitory concentration 50, leaves, lignans, neoplasms, nuclear magnetic resonance spectroscopy, spectral analysis
- Six new dihydrobenzofuran lignans, named illiciumlignans AF (compounds 16), along with 15 known compounds (721) were isolated from the branches and leaves of Illicium wardii. The structures of 16 were determined using a combination of 1D and 2D NMR, HR-ESI-MS, and CD spectroscopic data. Illiciumlignan D (4) is the first reported dihydrobenzofuran lignan arabinofuranoside that is derivatized with the arabinofuranose moiety on C-9⿲. Compounds 121 were evaluated for cytotoxic activity against four human cancer cell lines. Compounds 8, 12 and 20 exhibited significant activity against human cancer cell lines (A549, SKOV3, HepG2 and HCT116), with IC50 values ranging from 2.7 to 14.9μM.