Jump to Main Content
Phenylethanoid glycosides and phenolic glycosides from stem bark of Magnolia officinalis
- Xue, Zhenzhen, Yan, Renyi, Yang, Bin
- Phytochemistry 2016 v.127 pp. 50-62
- Magnolia officinalis, acarbose, alpha-glucosidase, chemical analysis, cytotoxicity, ethanol, glycosides, human cell lines, hydrolysis, hydrophilicity, inhibitory concentration 50, spectroscopy
- An investigation of the hydrophilic constituents of the stem bark of Magnolia officinalis was performed and which led to isolation and identification of twenty-one previously unreported glycosides. These included eleven phenylethanoid glycosides, magnolosides F–P, and ten phenolic glycosides, magnolosides Q–Z, along with eight known compounds. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical hydrolysis methods, as well as by comparison with literature data. Most of the phenylethanoid glycosides contained an allopyranose moiety, which is rare in the plant kingdom. Magnolosides I and K as well as 2-(3,4-dihydroxyphenyl) ethanol 1-O-[4-O-caffeoyl-2-O-α-l-rhamnopyranosyl-3-O-α-l-rhamnopyranosyl-6-O-β-d-glucopyranosyl]-β-d-glucopyranoside showed more potent α-glucosidase inhibitory effects (IC50 values of 0.13, 0.27, and 0.29mM, respectively) than the positive control, acarbose (IC50 value of 1.09mM) in vitro. Magnolosides H, E and D also showed moderate cytotoxicity against MGC-803 and HepG2 cells with IC50 values of 13.59–17.16μM and 29.53–32.46μM, respectively.