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Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

Author:
Grecco, Simone S., Reimão, Juliana Q., Tempone, Andre G., Sartorelli, Patricia, Romoff, Paulete, Ferreira, Marcelo J. P., Fávero, Oriana A., Lago, Joao H. G.
Source:
Parasitology research 2010 v.106 no.5 pp. 1245-1248
ISSN:
0932-0113
Subject:
Baccharis, Leishmania, Trypanosoma cruzi, chromatography, flora, fractionation, leaf extracts, leaves, mass spectrometry, methylene chloride, nuclear magnetic resonance spectroscopy
Abstract:
In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4′-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.
Agid:
525666