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Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells

Xu, Jing, Sun, Xiaocong, Liu, Xingyu, Peng, Maoqin, Li, Shen, Jin, Da-Qing, Lee, Dongho, Bartlam, Mark, Guo, Yuanqiang
Journal of functional foods 2016 v.23 pp. 565-572
Alzheimer disease, Melicope, bioactive compounds, food plants, functional foods, medical treatment, nerve growth factor, neurites, nuclear magnetic resonance spectroscopy, spectral analysis, stems
Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote neurite outgrowth. A bioassay-guided phytochemical investigation led to the isolation of four new chroman derivatives, pteleifolones A–D (1–4), and nine known components, acronyculatin B (5), acronylin (6), marmesin (7), 5-methoxymarmesin (8), (+)-peucedanol (9), atanine (10), N-methylatanine (11), dictamnine (12), and evolitrine (13). Their structures were established by extensive nuclear magnetic resonance (NMR) spectroscopic data analysis. Most of these compounds promoted nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. These chemical and biological results provide a basis for the further development and utilization of M. pteleifolia as a functional food.