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Study on the Anticorrosion, Biocompatibility, and Osteoinductivity of Tantalum Decorated with Tantalum Oxide Nanotube Array Films

Author:
Wang, Na, Li, Hongyi, Wang, Jinshu, Chen, Su, Ma, Yuanping, Zhang, Zhenting
Source:
ACS Applied Materials & Interfaces 2012 v.4 no.9 pp. 4516-4523
ISSN:
1944-8252
Subject:
actin, adsorption, annealing, biocompatibility, bone formation, bovine serum albumin, coatings, cytoskeleton, fibronectins, fluorescence microscopy, gene expression, genes, messenger RNA, nanotubes, osteocalcin, quantitative polymerase chain reaction, rabbits, stem cells, tantalum
Abstract:
With its excellent anticorrosion and biocompatibility, tantalum, as a promising endosseous implant or implant coating, is attracting more and more attention. For improving physicochemical property and biocompatibility, the research of tantalum surface modification has increased. Tantalum oxide (Ta₂O₅) nanotube films can be produced on tantalum by controlling the conditions of anodization and annealing. The objective of our present study was to investigate the influence of Ta₂O₅ nanotube films on pure tantalum properties related with anticorrosion, protein adsorption, and biological function of rabbit bone mesenchymal stem cells (rBMSCs). The polarization curve was measured, the adsorption of bovine serum albumin and fibronectin to Ta₂O₅ nanotubes was detected, and the morphology and actin cytoskeletons of the rBMSCs were observed via fluorescence microscopy, and the adhesion and proliferation of the rBMSCs, as well as the osteogenic differentiation potential on tantalum specimens, were examined quantificationally by MTT and real-time PCR technology. The results showed that Ta₂O₅ nanotube films have high anticorrosion capability and can increase the protein adsorption to tantalum and promote the adhesion, proliferation, and differentiation of rBMSCs, as well as the mRNA expression of osteogenic gene such as Osterix, ALP, Collagen-I, and Osteocalcin on tantalum. This study suggests that Ta₂O₅ nanotube films can improve the anticorrosion, biocompatibility, and osteoinduction of pure tantalum, which provides the theoretical elaboration for development of tantalum endosseous implant or implant coating to a certain extent.
Agid:
5274244