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An Approach to Prepare Polyethylenimine Functionalized Silica-Based Spheres with Small Size for siRNA Delivery
- Yu, Meihua, Niu, Yuting, Yang, Yannan, Hartono, Sandy Budi, Yang, Jie, Huang, Xiaodan, Thorn, Peter, Yu, Chengzhong
- ACS Applied Materials & Interfaces 2014 v.6 no.18 pp. 15626-15631
- colorectal neoplasms, humans, neoplasm cells, osteosarcoma, polyethyleneimine, silica, small interfering RNA
- A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of ∼10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.