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Three new 3-methyl-2-arylbenzofurans from the fermentation products of an endophytic fungus Phomopsis sp. and their anti-TMV activity

Author:
Du, Gang, Wang, Zhong-Cheng, Hu, Wei-Yao, Yan, Ke-Liang, Wang, Xin-Lin, Yang, Hong-Mei, Yang, Hai-Ying, Gao, Yu-Hong, Liu, Qiang, Hu, Qiu-Fen
Source:
Phytochemistry letters 2017 v.21 pp. 287-290
ISSN:
1874-3900
Subject:
Diaporthe, endophytes, fermentation, fungi, nuclear magnetic resonance spectroscopy, spectral analysis, viruses
Abstract:
Three new arylbenzofurans, 7-methoxy-2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran (1), 2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran-7-ol (2), 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-methyl-5-(3-prenyl)benzofuran-7-ol (3), along with four known arylbenzofurans (4–7) were isolated from the fermentation products of an endophytic Phomopsis sp. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. In addition, compounds 1–7 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 3 exhibited obvious anti-TMV activity with inhibition rate of 35.2% better than that of positive control (31.8%). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 18.6–25.7%, respectively.
Agid:
5278703