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Reduced Graphene Oxide/Amaranth Extract/AuNPs Composite Hydrogel on Tumor Cells as Integrated Platform for Localized and Multiple Synergistic Therapy

Author:
Chang, Guanru, Wang, Yunlong, Gong, Baoyou, Xiao, Yazhong, Chen, Yan, Wang, Shaohua, Li, Shikuo, Huang, Fangzhi, Shen, Yuhua, Xie, Anjian
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.21 pp. 11246-11256
ISSN:
1944-8252
Subject:
adverse effects, antineoplastic activity, biocompatibility, chlorophyll, cross-linking reagents, cytotoxicity, drugs, graphene oxide, hydrogels, hydrophilicity, irradiation, nanogold, neoplasm cells, photochemotherapy, reducing agents, singlet oxygen, temperature
Abstract:
Integration of multimodal treatment strategies combined with localized therapy to enhance antitumor efficacy and reduce side effects is still a challenge. Herein, a novel composite hydrogel containing rGO, amaranth extract (AE) and gold nanoparticles (AuNPs) was prepared by using AE as both reductant and cross-linking agent. The chlorophyll derivatives in AE were also employed as a photodynamic therapy drug. Meanwhile, AuNPs and rGO both have obvious photothermal effects and can accelerate the generation of cytotoxic singlet oxygen (¹O₂). The temperature increase of rGO/AE/AuNPs precursor is up to 6.3 °C under 808 nm laser irradiation at a power density of 200 mW·cm–². The hydrogel shell on in situ tumor cells was easily formed and regulated by near-infrared irradiation within 10 min, which could both retain a high concentration of drugs on the lesion site and prevent them from migrating to normal tissue, thus reducing the side effects. Compared with rGO/AE and AE, rGO/AE/AuNPs showed a remarkably improved and synergistic antitumor effect. The hydrogel possesses good biocompatibility and high hydrophilicity and could be used for loading chemotherapeutics, which provides a new approach for located and multiple antitumor therapies.
Agid:
5283097