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Dual-Peptide-Functionalized Albumin-Based Nanoparticles with pH-Dependent Self-Assembly Behavior for Drug Delivery
- Chen, Bin, He, Xiao-Yan, Yi, Xiao-Qing, Zhuo, Ren-Xi, Cheng, Si-Xue
- ACS Applied Materials & Interfaces 2015 v.7 no.28 pp. 15148-15153
- drug therapy, drugs, electrical charges, electrostatic interactions, ligands, nanoparticles, neoplasm cells, neoplasms, pH
- Drug delivery has become an important strategy for improving the chemotherapy efficiency. Here we developed a multifunctionalized nanosized albumin-based drug-delivery system with tumor-targeting, cell-penetrating, and endolysosomal pH-responsive properties. cRGD-BSA/KALA/DOX nanoparticles were fabricated by self-assembly through electrostatic interaction between cell-penetrating peptide KALA and cRGD-BSA, with cRGD as a tumor-targeting ligand. Under endosomal/lysosomal acidic conditions, the changes in the electric charges of cRGD-BSA and KALA led to the disassembly of the nanoparticles to accelerate intracellular drug release. cRGD-BSA/KALA/DOX nanoparticles showed an enhanced inhibitory effect in the growth of αᵥβ₃-integrin-overexpressed tumor cells, indicating promising application in cancer treatments.