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Polylactide-based Magnetic Spheres as Efficient Carriers for Anticancer Drug Delivery

Mhlanga, Nikiwe, Sinha Ray, Suprakas, Lemmer, Yolandy, Wesley-Smith, James
ACS Applied Materials & Interfaces 2015 v.7 no.40 pp. 22692-22701
Fourier transform infrared spectroscopy, biocompatibility, coprecipitation, doxorubicin, evaporation, hydrophobicity, iron oxides, models, nanoparticles, neoplasm cells, neoplasms, oleic acid, pH, polylactic acid, scanning electron microscopy, solvents, transmission electron microscopy, ultraviolet-visible spectroscopy, zeta potential
To improve traditional cancer therapies, we synthesized polylactide (PLA) spheres coencapsulating magnetic nanoparticles (MNPs, Fe₃O₄) and an anticancer drug (doxorubicin, DOX). The synthesis process involves the preparation of Fe₃O₄ NPs by a coprecipitation method and then PLA/DOX/Fe₃O₄ spheres using the solvent evaporation (oil-in-water) technique. The Fe₃O₄ NPs were coated with oleic acid to improve their hydrophobicity and biocompatibility for medical applications. The structure, morphology and properties of the MNPs and PLA/DOX/Fe₃O₄ spheres were studied using various techniques, such as FTIR, SEM, TEM, TGA, VSM, UV–vis spectroscopy, and zeta potential measurements. The in vitro DOX release from the spheres was prolonged, sustained, and pH-dependent and fit a zero-order kinetics model and an anomalous mechanism. Interestingly, the spheres did not show a DOX burst effect, ensuring the minimal exposure of the healthy cells and an increased drug payload at the tumor site. The pronounced biocompatibility of the PLA/DOX/Fe₃O₄ spheres with HeLa cells was proven by a WST assay. In summary, the synthesized PLA/DOX/Fe₃O₄ spheres have the potential for magnetic targeting of tumor cells to transform conventional methods.