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Bifunctional Magnetic-Fluorescent Nanoparticles: Synthesis, Characterization, and Cell Imaging

Author:
Lu, Yanjiao, Zheng, Yang, You, Shusen, Wang, Feng, Gao, Zhuo, Shen, Jie, Yang, Wantai, Yin, Meizhen
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.9 pp. 5226-5232
ISSN:
1944-8252
Subject:
ambient temperature, biocompatibility, cell viability, coatings, fluorescence, image analysis, nanoparticles, polymers, spectroscopy, transmission electron microscopy
Abstract:
A new type of bifunctional magnetic-fluorescent Fe₃O₄@SiO₂–PDI–PAA/Ca²⁺ nanoparticles has been prepared by coating PDI-cored star polymers (PDI–PAA) onto the surface of Fe₃O₄@SiO₂ core–shell nanostructures. The morphology and properties of the composite nanoparticles are investigated by transmission electron microscopy, ultraviolet–visible spectrometry, fluorescence spectrometry, and vibrating sample magnetometry. The composite nanoparticles display a strong red emission and superparamagnetic behavior at room temperature. The cell viability and uptake assays reveal good biocompatibility of these hybrid nanoparticles. Hence, the composite nanoparticles are of potential to be further explored as therapeutic vector in biomedical field.
Agid:
5288396