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Fabrication of Mesoporous Silica Nanoparticle with Well-Defined Multicompartment Structure as Efficient Drug Carrier for Cancer Therapy in Vitro and in Vivo

Author:
Wang, Anhe, Yang, Yang, Qi, Yanfei, Qi, Wen, Fei, Jinbo, Ma, Hongchao, Zhao, Jie, Cui, Wei, Li, Junbai
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.14 pp. 8900-8907
ISSN:
1944-8252
Subject:
antineoplastic agents, biocompatibility, biodegradability, calcium carbonate, drug carriers, nanoparticles, neoplasms, porous media, silica, vaterite
Abstract:
Vaterite particles are composed of particulate CaCO₃ nanoparticles, which offer an ideal platform to synthesize architectures with hierarchical structure. Herein we show that mesoporous silica particles with well-defined multicompartment structure are fabricated by employing vaterite particles as templates. The obtained silica particles inherited the structure feature of vaterite and had excellent biocompatibility and biodegradability. Moreover, the silica particles were established as an efficient anticancer drugs carrier compared with hollow silica particles, which could be applied in cancer therapy in vitro and in vivo. The silica particles obtained here offer a cheap, facile, environmentally friendly avenue to assembly of hierarchical drugs carriers.
Agid:
5288865