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Quantitative Response of IMS Detector for Mixtures Containing Two Active Components

Author:
Puton, Jarosław, Holopainen, Sanna I., Mäkinen, Marko A., Sillanpää, Mika E. T.
Source:
Analytical chemistry 2012 v.84 no.21 pp. 9131-9138
ISSN:
1520-6882
Subject:
acetone, controllers, ions, mass flow, mathematical models, spectroscopy, trimethylamine, vapors
Abstract:
This study describes the relationship between the output signal of the ion mobility spectrometry (IMS) detector and the concentrations of two compounds being simultaneously introduced into the reaction section. Investigations were performed for three pairs of compounds, that is, dimethyl methylphosphonate (DMMP) and acetone, methyl tert-butyl ether (MTBE), and acetone, as well as trimethylamine (TMA) and n-nonylamine (NA). Vapors of the investigated compounds were produced in a two-channel generator with permeation sources and a dilution system based on mass-flow controllers. The generator design and the method of concentration determination are discussed in this paper. It was found that admixture can differently influence detection of an analyte. The presence of acetone does not effect the signal corresponding to dimer ions of DMMP. For pairs MTBE + acetone and TMA + NA characteristic peaks of analyte ions diminish with growing concentration of admixture, however, the detection based on the peak of the asymmetric dimer containing proton-bound molecules of both compounds is effective. For the detection of TMA in the presence of NA, the signal generated by the asymmetric dimer ions is meaningfully higher than the signals of monomer or dimer TMA ions measured without the NA admixture. The course of calibration dependencies was analyzed on the basis of a simple mathematical model of the reaction region. This model provided an estimation of the intensity of the signal for a given ionic species for definite concentration of analyte.
Agid:
5291244