Jump to Main Content
Truncaquinones A and B, asterriquinones from Annulohypoxylon truncatum
- Surup, Frank, Wiebach, Vincent, Kuhnert, Eric, Stadler, Marc
- Tetrahedron letters 2016 v.57 pp. 2183-2185
- Gram-positive bacteria, chemical reactions, chemical structure, cytotoxicity, fruiting bodies, fungi, high performance liquid chromatography, nuclear magnetic resonance spectroscopy, organic compounds, pigments, secondary metabolites, Texas
- Stromata (fruiting bodies) from the xylariaceous fungus Annulohypoxylon truncatum collected in Texas were analyzed for novel secondary metabolites. Two asterriquinone-type pigments named truncaquinones A (1) and B (2) were obtained by preparative HPLC in addition to the known truncatone. Their structures were elucidated by HRESIMS and NMR data. 4J correlations were crucial to assign a methoxy signal in 1; these were observed in HMBC spectra with extended long range evolution delay (Δ) times. The pigments exhibited cytotoxic effects besides weak activity against Gram positive bacteria.