Jump to Main Content
An insulin-binding protein from the venom of a solitary wasp Eumenes pomiformis binds to apolipophorin III in lepidopteran hemolymph
- Baek, Ji Hyeong, Lee, Si Hyeock, Kim, Woe-Yeon, Kim, Min Gab
- Toxicon 2016 v.111 pp. 62-64
- Hymenoptera, Spodoptera exigua, apolipophorin, bioactive properties, body weight changes, hemolymph, larvae, metabolism, starvation, survival rate, venoms
- EpIBP, an insulin-like peptide-binding protein, is a major protein component of the venom of a solitary hunting wasp, Eumenes pomiformis. To evaluate the bioactivity, bacteria-expressed EpIBP was injected into Spodoptera exigua larvae, resulting in a higher survival rate and reduced loss of body weight under starvation conditions than control larvae. EpIBP was found to interact with apolipophorin III (apoLp III), implying that EpIBP might function by altering the apoLp III-mediated metabolism of prey.