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Bioluminescence Probe for Detecting Hydrogen Sulfide in Vivo

Author:
Ke, Bowen, Wu, Wenxiao, Liu, Wei, Liang, Hong, Gong, Deying, Hu, Xiaotong, Li, Minyong
Source:
Analytical chemistry 2016 v.88 no.1 pp. 592-595
ISSN:
1520-6882
Subject:
bioluminescence, hydrogen sulfide, in vivo studies, monitoring
Abstract:
Considering that hydrogen sulfide (H₂S) is an endogenous signaling molecule involved in numerous biological processes, a method for monitoring H₂S as a powerful tool for investigating its complicated functions and mechanisms is urgently demanded. Herein, a bioluminescent turn-on probe was reported based on caged strategy for the detection of H₂S in vitro and in vivo. This probe will help us understand the intricate contribution of H₂S to a variety of physiological and pathological processes.
Agid:
5301270