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Identification of a novel transcript of human MD2 gene
- Shen, Chen, Shen, A-dong
- Gene 2016 v.590 no.1 pp. 123-127
- Toll-like receptor 4, bioactive properties, exons, genes, humans, immune response, lipopolysaccharides, protein structure, spliceosomes
- Myeloid differentiation protein 2 (MD2) regulates bacterial lipopolysaccharide (LPS) triggered anti-bacterial immune response as a broker between LPS and Toll-like receptor 4 (TLR4). In this study, we identified a novel naturally occurring spliceosome of human MD2, termed as MD2-T3. This transcript lacked two exons of MD2 gene. By protein structure analysis and literature review, we predicted that MD2-T3 isoform might execute regulatory biological effects such as limiting LPS-triggered TLR4 signaling.