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PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis

Author:
Fiume, Roberta, Jones, David R., Divecha, Nullin
Source:
Trends in biochemical sciences 2016 v.41 no.6 pp. 473-475
ISSN:
0968-0004
Subject:
carcinogenesis, cell growth, guanosine triphosphate, mammals, neoplasm cells
Abstract:
Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.
Agid:
5302221