Jump to Main Content
PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis
- Fiume, Roberta, Jones, David R., Divecha, Nullin
- Trends in biochemical sciences 2016 v.41 no.6 pp. 473-475
- carcinogenesis, cell growth, guanosine triphosphate, mammals, neoplasm cells
- Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.