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Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed
- Patel, Sandip, Penny, Christopher J., Rahman, Taufiq
- Trends in biochemical sciences 2016 v.41 no.6 pp. 475-477
- animals, calcium, ion channels, vacuoles
- Two-pore channels (TPCs) are intracellular Ca²⁺-permeable ion channels that are expressed on acidic Ca²⁺ stores. They are co-regulated by voltage and Ca²⁺ in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.