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Cardiopulmonary effects of two constant rate infusions of dexmedetomidine in isoflurane anaesthetized ponies

Marcilla, Miguel Gozalo, Schauvliege, Stijn, Duchateau, Luc, Gasthuys, Frank
Veterinary anaesthesia and analgesia 2010 v.37 no.4 pp. 311-321
analysis of variance, anesthesia, blood, dexmedetomidine, electrocardiography, gases, heart rate, horses, intravenous injection, isoflurane, ketamine, models, monitoring, normal values, oxygen, systolic blood pressure
To evaluate the cardiopulmonary effects of two different constant rate infusions (CRI) of dexmedetomidine (1 and 1.75 μg kg⁻¹ hour⁻¹) in experimental ponies. Six healthy ponies (mean 306 ± SD 71 kg, 7.0 ± 1.6 years). Prospective, randomized, experimental study. After premedication with intravenous (IV) dexmedetomidine (3.5 μg kg⁻¹), anaesthesia was induced (T0) with ketamine (2.2 mg kg⁻¹ IV) and midazolam (0.06 mg kg⁻¹ IV) and maintained with isoflurane (F e′ISO 1.50%) in 55% oxygen for 150 minutes. Normocapnia was maintained using artificial ventilation. Three ponies received dexmedetomidine CRIs of 1 and 1.75 μg kg⁻¹ hour⁻¹ from T30 to T60 and T90 to T120 respectively. In the other three ponies, the order of the doses was reversed. Continuous monitoring included pulse oximetry, electrocardiography, anaesthetic gas monitoring, arterial and central venous pressures. Cardiac ouput (LiDCO technique) was measured and arterial and venous bloods taken every 15 minutes. Cardiac index (CI), systemic vascular resistance (SVR), arterial and venous oxygen content (CaO₂, CvO₂) and oxygen delivery (&Ddot;O₂) were calculated. Analysis of variance with separate models for each CRI rate was used to detect differences between values obtained at the end of the CRI and their respective baseline values. A mixed model with these differences as response variable, pony as random effect and treatment and period as fixed effects was applied to find differences between the two CRIs (α = 0.05 for all analyses). Heart rate (HR), CI, CaO₂, CvO₂ and &Ddot;O₂ decreased significantly, while significant increases were found in SVR, systolic arterial pressure and right atrial pressure with both infusion rates. No differences were found between the two dexmedetomidine CRI rates. Although significant, cardiopulmonary effects of the dexmedetomidine CRIs in isoflurane anaesthetized ponies were small, without differences between the two dose rates.