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A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum
- Abdelhady, Mohamed I.S., Motaal, Amira Abdel
- Revista Brasileira de Farmacognosia 2016 v.26 no.6 pp. 763-766
- Ocimum basilicum, antioxidant activity, apigenin, butanol, chromatography, cinnamic acid, colorectal neoplasms, cytotoxicity, ellagic acid, ethanol, ethyl acetate, gallic acid, humans, inhibitory concentration 50, leaves, luteolin
- The standardized 80% ethanolic extract of the leaves of Ocimum basilicum var. thyrsiflorum (L.) Benth., Lamiaceae, growing in KSA, exhibited a significant antioxidant activity compared to the ethyl acetate and butanol extracts, which was correlated to its higher phenolic and flavonoid contents. Chromatographic separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3″-O-acetylvitexin. Compound 3″-O-acetylvitexin, a C-glycosylated derivative of apigenin, was isolated for the first time from genus Ocimum. The 80% ethanolic extract and 3″-O-acetylvitexin showed significant cytotoxic activities against the HCT116 human colon cancer cell line [IC50 values 22.3±1.1 and 16.8±2.0μg/ml (35.4μM), respectively].