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Interleukin-27 inhibits foam cell formation by promoting macrophage ABCA1 expression through JAK2/STAT3 pathway

Fu, Hui, Tang, Yan-yan, Ouyang, Xin-ping, Tang, Shi-lin, Su, Hua, Li, Xiaotao, Huang, Li-ping, He, Miao, Lv, Yun-cheng, He, Ping-ping, Yao, Feng, Tan, Yu-lin, Xie, Wei, Zhang, Min, Wu, Jianfeng, Li, Yuan, Chen, Kong, Liu, Dan, Lan, Gang, Zeng, Meng-ya, Zheng, Xi-long, Tang, Chao-ke
Biochemical and biophysical research communications 2014 v.452 pp. 881-887
cholesterol, foam cells, messenger RNA, non-specific protein-tyrosine kinase, signal transduction, transactivators
The purpose of this study is to determine whether IL-27 regulates macrophage ABCA1 expression, foam cell formation, and also explore the underlying mechanisms. Here, we revealed that IL-27 decreased lipid accumulation in THP-1 derived macrophages through markedly enhancing cholesterol efflux and increasing ABCA1 expression at both protein and mRNA levels. Our study further demonstrated that IL-27 increased ABCA1 level via activation of signal transducer and activator of transcription 3 (STAT3). Inhibition of Janus kinase 2, (JAK2)/STAT3 suppressed the stimulatory effects of IL-27 on ABCA1 expression. The present study concluded that IL-27 reduces lipid accumulation of foam cell by upregulating ABCA1 expression via JAK2/STAT3. Therefore, targeting IL-27 may offer a promising strategy to treat atherosclerotic vascular disease.