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Meningoencephalitis in a Dog Due to Trichosporon montevideense

Author:
Bryan, L.K., Porter, B.F., Wickes, B.L., Spaulding, K.A., Kerwin, S.C., Lawhon, S.D.
Source:
Journal of comparative pathology 2014 v.151 no.2-3 pp. 157-161
ISSN:
0021-9975
Subject:
DNA, Trichosporon, cerebrum, dogs, fungi, genes, hyphae, in situ hybridization, inflammation, internal transcribed spacers, meningoencephalitis, ribosomal RNA, sequence analysis
Abstract:
Meningoencephalitis due to infection with Trichosporon montevideense was diagnosed in a 4-year-old dog with a brief clinical history of rapidly progressing neurological signs that culminated in a comatose state. No significant gross lesions were found at post-mortem examination. Microscopically, a few scattered areas of pyogranulomatous inflammation with a few small, non-pigmented fungal hyphae were found within the cerebrum surrounding the lateral ventricles. A Trichosporon sp. was identified through culture of the brain and species was determined via sequence analysis of the internal transcribed spacer region of the Trichosporon rRNA gene. DNA in-situ hybridization confirmed the diagnosis. This is the first reported case of Trichosporon-associated meningoencephalitis in a dog.
Agid:
5337382