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The weight of obesity on the human immune response to vaccination
- Painter, Scott D., Ovsyannikova, Inna G., Poland, Gregory A.
- Vaccine 2015 v.33 no.36 pp. 4422-4429
- adipocytes, adipose tissue, body mass index, humans, immune response, immune system, infectious diseases, lipids, obesity, patients, risk, vaccination, vaccines
- Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the likelihood of a poor vaccine-induced immune response. Obesity occurs through the deposition of excess lipids into adipose tissue through the production of adipocytes, and is defined as a body-mass index (BMI)≥30kg/m2. The immune system is adversely affected by obesity, and these “immune consequences” raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected.