U.S. flag

An official website of the United States government

PubAg

Main content area

Efficacy of afoxolaner against Ixodes scapularis ticks in dogs

Author:
Mitchell, Elizabeth B., McCall, John W., Theodore Chester, S., Larsen, Diane
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 223-225
ISSN:
0304-4017
Subject:
Beagle, Ixodes scapularis, acaricides, adults, dogs, insecticides, oral administration, ticks
Abstract:
Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Ixodes scapularis was evaluated in a laboratory study. One day prior to treatment, beagle dogs (n=16) were infested with 50 unfed wild adult ticks. Repeat infestations were performed weekly for four additional weeks. The number of live ticks remaining on each dog was determined 48h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
Agid:
5352819