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Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish

Author:
Fang, Qi, Shi, Qipeng, Guo, Yongyong, Hua, Jianghuan, Wang, Xianfeng, Zhou, Bingsheng
Source:
Environmental Science & Technology 2016 v.50 no.2 pp. 1005-1013
ISSN:
1520-5851
Subject:
Danio rerio, animal ovaries, aquatic environment, aquatic organisms, bioaccumulation, bioavailability, bisphenol A, brain, egg production, estradiol, females, follicle-stimulating hormone, histology, liver, luteinizing hormone, males, nanoparticles, plant ovary, pollution, testes, testosterone, tissues, titanium dioxide, toxicity, vitellogenin
Abstract:
Titanium dioxide nanoparticles (n-TiO₂) and bisphenol A (BPA) are widespread environmental contaminants in the aquatic environment. We hypothesized that n-TiO₂ may adsorb BPA, and thus modify its bioavailability and toxicity to aquatic organisms. In this study, the bioavailability and toxicity of BPA (0, 2, 20, 200 μg/L) was investigated in the presence of n-TiO₂ (100 μg/L). The n-TiO₂ sorbed BPA and the resulting nanoparticles were taken up by zebrafish, where they translocated to the liver, brain, and gonad tissues. Increased tissue burdens of both BPA and n-TiO₂ were observed following coexposure, and they also caused a reduction in plasma concentrations of estradiol (E₂), testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Plasma vitellogenin (VTG) concentrations were significantly increased in males and females upon exposure to BPA. Histological examination of the ovary and testes did not show obvious morphological alterations; however, inhibition of egg production was noted in the presence of n-TiO₂. The results indicated that n-TiO₂ acts as a carrier of BPA and enhances its bioconcentration in zebrafish, leading to endocrine disruption and impairment of reproduction.
Agid:
5363538