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Comparative Toxicity of High-Molecular Weight Iopamidol Disinfection Byproducts
- Wendel, Friedrich
M., Ternes, Thomas A., Richardson, Susan D., Duirk, Stephen E., Pals, Justin A., Wagner, Elizabeth D., Plewa, Michael J.
- Environmental Science & Technology Letters 2016 v.3 no.3 pp. 81-84
- X-radiation, byproducts, chlorination, cytotoxicity, disinfection, environmental science, genotoxicity, mammals, mutagens
- When the X-ray contrast pharmaceutical iopamidol was chlorinated in natural source water, a toxic mixture of many disinfection byproducts (DBPs) was formed. We isolated and identified five high-molecular weight iopamidol chlorination DBPs and analyzed their cytotoxicity and genotoxicity using mammalian cells. Of the five DBPs, four exhibited low levels of cytotoxicity, while none of the iopamidol DBPs was genotoxic. These data support the hypothesis that these high-molecular weight DBPs were not the forcing agents that induced the cytotoxicity and genotoxicity observed after iopamidol was disinfected in natural source waters.