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Application of Mechanochemical Pretreatment Prior to Aqueous Extraction of Eleutheroside B from Eleutherococcus senticosus

Jin, Liji, Li, Huaqiang, Wu, Feifei, Li, Xiaoyu, Yu, Haibo, Cui, Naizhong, You, Jiansong, Cao, Zhenhui, Sun, Xiuhua, Zhang, Jiancheng, Wang, Xiaoli, Song, Chunna, Li, Shuying, Xu, Yongping
Industrial & Engineering Chemistry Research 2012 v.51 no.32 pp. 10695-10701
Eleutherococcus senticosus, chemistry, engineering, experimental design, particle size, solvents, sustainable technology, water temperature
A mechanochemical pretreatment was used prior to aqueous extraction of eleutheroside B from Eleutherococcus senticosus. The effects of the mechanochemical assisted extraction parameters hydroxypropyl-β-cyclodextrin (HP-β-CD) content, particle size, and circulating water temperature on the extraction yield of eleutheroside B were investigated. The mechanochemical assisted extraction process was optimized based on an orthogonal experimental design. The optimum process conditions were a HP-β-CD content of 23% (w/w), a particle size of D₉₅ ≤ 44 μm and circulating water temperature of 40 °C. The mechanochemical assisted extraction process produced a higher eleutheroside B extraction yield, using a shorter extraction time and a greatly simplified process compared with traditional heat-reflux extraction, which makes mechanochemical assisted extraction a potential tool for eleutheroside B extraction from Eleutherococcus senticosus. Moreover, this technique used water as the solvent, making mechanochemical assisted extraction a less expensive and eco-friendly technique compared with traditional heat-reflux extraction.