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Pathogenicity comparison between highly pathogenic and NADC30-like porcine reproductive and respiratory syndrome virus
- Sun, Zhe, Wang, Juan, Bai, Xiaofei, Ji, Guobiao, Yan, He, Li, Yingying, Wang, Yuzhou, Tan, Feifei, Xiao, Yan, Li, Xiangdong, Tian, Kegong
- Archives of virology 2016 v.161 no.8 pp. 2257-2261
- Porcine reproductive and respiratory syndrome virus, antibodies, fever, histopathology, respiratory tract diseases, swine, virulence, viruses
- The pathogenicity of HNjz15, an NADC30-like strain of porcine reproductive and respiratory syndrome virus (PRRSV), was investigated and compared to that of a highly pathogenic PRRSV JAX1 strain. Six-week-old pigs infected with each virus showed typical clinical symptoms, including high fever and respiratory disorders. Pigs infected with JXA1 had more-severe clinical manifestations than pigs infected with HNjz15. HNjz15 replicated in vivo with kinetics similar to those of JXA1 but induced a lower level of PRRSV-specific antibody at the beginning of virus infection. Histopathologically, JXA1 infection led to more-severe lung lesions and broader organ tropism than HNjz15 did. Different from what was observed with the previously reported NADC30-like PRRSV JL580 strain, all HNjz15-infected pigs survived until the end of the study. All of these results indicated that NADC30-like PRRSV HNjz15 is virulent to pigs but is less pathogenic than the JXA1 and JL580 PRRSV strains.