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Pathogenicity comparison between highly pathogenic and NADC30-like porcine reproductive and respiratory syndrome virus

Sun, Zhe, Wang, Juan, Bai, Xiaofei, Ji, Guobiao, Yan, He, Li, Yingying, Wang, Yuzhou, Tan, Feifei, Xiao, Yan, Li, Xiangdong, Tian, Kegong
Archives of virology 2016 v.161 no.8 pp. 2257-2261
Porcine reproductive and respiratory syndrome virus, antibodies, fever, histopathology, respiratory tract diseases, swine, virulence, viruses
The pathogenicity of HNjz15, an NADC30-like strain of porcine reproductive and respiratory syndrome virus (PRRSV), was investigated and compared to that of a highly pathogenic PRRSV JAX1 strain. Six-week-old pigs infected with each virus showed typical clinical symptoms, including high fever and respiratory disorders. Pigs infected with JXA1 had more-severe clinical manifestations than pigs infected with HNjz15. HNjz15 replicated in vivo with kinetics similar to those of JXA1 but induced a lower level of PRRSV-specific antibody at the beginning of virus infection. Histopathologically, JXA1 infection led to more-severe lung lesions and broader organ tropism than HNjz15 did. Different from what was observed with the previously reported NADC30-like PRRSV JL580 strain, all HNjz15-infected pigs survived until the end of the study. All of these results indicated that NADC30-like PRRSV HNjz15 is virulent to pigs but is less pathogenic than the JXA1 and JL580 PRRSV strains.