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Anti‐acetylcholinesterase, antidiabetic, anti‐inflammatory, antityrosinase and antixanthine oxidase activities of Moroccan propolis

Author:
El‐Guendouz, Soukaina, Aazza, Smail, Lyoussi, Badiaâ, Antunes, Maria D., Faleiro, Maria L., Miguel, Maria G.
Source:
International journal of food science & technology 2016 v.51 no.8 pp. 1762-1773
ISSN:
0950-5423
Subject:
acetylcholinesterase, alpha-amylase, alpha-glucosidase, enzyme inhibition, flavanones, flavones, hyaluronoglucosaminidase, inhibitory concentration 50, lipoxygenase, markets, phenol, propolis, xanthine oxidase, Morocco
Abstract:
Biological properties of Moroccan propolis have been scarcely studied. In the present work, the total phenols and flavonoids from 21 samples of propolis collected in different places of Morocco or 3 supplied in the market were determined, as well as the in vitro capacity for inhibiting the activities of acetylcholinesterase, α‐glucosidase, α‐amylase, lipoxygenase, tyrosinase, xanthine oxidase and hyaluronidase. The results showed that samples 1 (region Fez‐Boulemane, Sefrou city) (IC₅₀ = 0.065, 0.006, 0.020, 0.050, 0.014 mg mL⁻¹) and 23 (marketed) (IC₅₀ = 0.018, 0.002, 0.046, 0.037, 0.008 mg mL⁻¹) had the best in vitro capacity for inhibiting the α‐amylase, α‐glucosidase, lipoxygenase, tyrosinase and xanthine oxidase activities, respectively. A negative correlation between IC₅₀ values and concentration of phenols, flavones and flavanones was found. These activities corresponded to the generally higher amounts of phenols and flavonoids. In the same region, propolis samples have dissimilar phenol content and enzyme inhibitory activities.
Agid:
5373508