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Palladium-Mediated Cell-Surface Labeling

Author:
Spicer, Christopher D., Triemer, Therese, Davis, Benjamin G.
Source:
Journal of the American Chemical Society 2012 v.134 no.2 pp. 800-803
ISSN:
1520-5126
Subject:
Escherichia coli, amino acids, catalysts, cell death, chemical bonding
Abstract:
Benign C–C bond formation at various sites in cell-surface channels has been achieved through Suzuki–Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.
Agid:
5385403