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Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature

Author:
Mu, Xin, Wu, Tao, Wang, Hao-yang, Guo, Yin-long, Liu, Guosheng
Source:
Journal of the American Chemical Society 2012 v.134 no.2 pp. 878-881
ISSN:
1520-5126
Subject:
alkenes, ambient temperature, catalysts, catalytic activity, indoles, oxidation, palladium
Abstract:
A palladium-catalyzed intramolecular oxidative aryltrifluoromethylation reaction of activated alkenes has been explored. The reaction allows for an efficient synthesis of a variety of CF₃-containing oxindoles. Preliminary mechanistic study indicated that the reaction involves a Cₛₚ₃–Pdᴵⱽ(CF₃) intermediate, which undergoes reductive elimination to afford a Cₛₚ₃–CF₃ bond.
Agid:
5385442