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miR-374a promotes cell proliferation, migration and invasion by targeting SRCIN1 in gastric cancer
- Xu, Xinyun, Wang, Weijun, Su, Ning, Zhu, Xujun, Yao, Jun, Gao, Wenchao, Hu, Zhiqian, Sun, Yanping
- FEBS letters 2015 v.589 pp. 407-413
- cell proliferation, humans, microRNA, oncogenes, stomach neoplasms, tissues
- MicroRNAs (miRNAs) play a prominent role in gastric cancer (GC) initiation and progression. In this study, we found that miR-374a expression was up-regulated in human GC cell lines and tissues. Inhibition of miR-374a suppressed GC cell proliferation, migration and invasion in vitro and slowed tumor growth in vivo. SRC kinase signaling inhibitor 1 (SRCIN1) was identified as a direct target of miR-374a. Silencing of SRCIN1 significantly enhanced cell proliferation, migration and invasion, whereas SRCIN1 reintroduction partially abrogated the oncogenic effects of miR-374a. Taken together, these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1. miR-374a may therefore be useful as a promising therapeutic target for malignant GC.