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Multimodal Plasmonic Assay of Copper(II) Ion via Stimuli-Responsive State Transformation of Silver Molecular Nanoparticles
- Chen, Yang, Yin, Danyang, Ma, Yanyan, Bie, Zijun, Liu, Zhen
- Analytical chemistry 2016 v.88 no.16 pp. 8123-8128
- blood serum, colorimetry, copper, diagnostic techniques, environmental assessment, humans, nanoparticles, optical properties, silver
- Molecular nanoparticles (MNPs) have gained increased attention recently due to their unique structures and properties. However, their applications remain largely unexplored. Herein, we present an Ag MNPs-based multimodal plasmonic assay. This assay relied on changes in optical properties due to stimuli-responsive state trans-formation from MNPs to plasmonic nanoparticles (PNPs). As a proof-of-concept, naked-eye colorimetric assay, spectrophotometric assay and “turn-on” Raman assay of Cu²⁺ were developed. The feasibility of this approach for real-world applications was demonstrated with the determination of Cu²⁺ in human serum. This multimodal plasmonic assay exhibited several significant advantages, including selectivity, sensitivity, label-free nature, and multimodal capability. Because of these merits, Ag MNPs could be promising nanosensors for wide important applications such as diagnostics and environmental analysis.