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Development of a synbiotic product for newborns and infants
- Mazzola, Giuseppe, Aloisio, Irene, Biavati, Bruno, Di Gioia, Diana
- Lebensmittel-Wissenschaft + [i.e. und] Technologie 2015 v.64 no.2 pp. 727-734
- Bifidobacterium breve, arabinogalactans, bile salts, freeze drying, fructooligosaccharides, galactooligosaccharides, gastric juice, glucooligosaccharides, guar gum, hydrolysis, inulin, lipids, microencapsulation, neonates, pH, pathogens, polymerization, prebiotics
- The capability of ten commercial fibers of selectively stimulating the growth of four Bifidobacterium strains were studied with the purpose of developing a synbiotic product for infants. Two galacto-oligosaccharides (GOS), one fructo-oligosaccharide (sc-FOS), four inulins with different polymerization degree (DP), a gluco-oligosaccharide, an arabinogalactan and a hydrolyzed guar gum were used (10 gl−1). The prebiotic score was calculated comparing the capability of the fibers of stimulating the growth of bifidobacteria compared to infant pathogens. GOS, sc-FOS, low DP inulin (oligofructose) and the gluco-oligosaccharide could stimulate growth. However, the fibers showing the highest prebiotic score were oligofructose (Orafti®HIS), sc-FOS (Actilight®950P) and the GOS Vivinal®. Lyophilized strain survival in simulated gastro-intestinal conditions was also assayed to define suitable ways of administration. Survival in gastric juice at pH 2.5 was poor, whereas it was higher at pH 4, a value closer to newborn pH. Microencapsulation in a lipid matrix ensured strain survival also at pH 2.5. Survival to 1 gl−1 bile salts was acceptable. The results allowed to conclude that Bifidobacterium breve B632 strain, in a lyophilized or microencapsulated form, has the potential for use in synbiotic products targeted to infants coupled to a mixture of GOS and FOS or oligofructose.