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Influence of Backbone Conformational Rigidity in Temperature-Sensitive Amphiphilic Supramolecular Assemblies
- Raghupathi, Krishna
R., Sridhar, Uma, Byrne, Kevin, Raghupathi, Kishore, Thayumanavan, S.
- Journal of the American Chemical Society 2015 v.137 no.16 pp. 5308-5311
- encapsulation, hydrogen bonding, temperature
- Molecular design features that endow amphiphilic supramolecular assemblies with a unique temperature-sensitive transition have been investigated. We find that conformational rigidity in the backbone is an important feature for eliciting this feature. We also find that intramolecular hydrogen-bonding can induce such rigidity in amphiphile backbone. Guest encapsulation stability of these assemblies was found to be significantly altered within a narrow temperature window, which correlates with the temperature-sensitive size transition of the molecular assembly. Molecular design principles demonstrated here could have broad implications in developing future temperature-responsive systems.