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Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters
- Woźniak, Łukasz, Murphy, John J., Melchiorre, Paolo
- Journal of the American Chemical Society 2015 v.137 no.17 pp. 5678-5681
- ambient temperature, enantiomers, iodides, lighting
- The visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters is described. The photo-organocatalytic process, which occurs at ambient temperature and under visible light illumination, is triggered by the photochemical activity of in situ-generated electron donor–acceptor complexes, arising from the association of chiral enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.