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5-Lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos

Author:
Lim, Hyun, Son, Kun Ho, Bae, Ki Hwan, Hung, Tran Manh, Kim, Yeong Shik, Kim, Hyun Pyo
Source:
Phytotherapy research 2009 v.23 no.10 pp. 1489-1492
ISSN:
0951-418X
Subject:
Magnolia, Schisandra, ethers, leukemia, medicine, prostaglandins, rats
Abstract:
In order to establish the antiallergic properties of Schisandra fructus and Magnolia flos, several compounds isolated from these plants were tested for 5-lipoxygenase (5-LOX) inhibitory activity in vitro, for the first time. The compounds including schizandrins, schisandrols, gomisins, fargesin, eudesmin and lirioresinol B dimethyl ether, inhibited 5-LOX-catalysed leukotriene production from A23187-treated rat basophilic leukemia (RBL-1) cells at concentrations of 1-100 μm. In particular, constituents such as schisandrol A and gomisins showed potent inhibitory activity (IC₅₀s < 10 μm) on 5-LOX-catalysed leukotriene production, but were much less active on cyclooxygenase-2-catalysed prostaglandin E₂ and inducible nitric oxide-catalysed NO production. These compounds have the potential to be developed as novel antiallergic agents and may contribute to the antiallergic pharmacological use of these plant materials in Chinese medicine.
Agid:
541690